http://www.livestrong.com/article/102947-botox-treatments-interstitial-cystitis/
pr 7, 2010 | By
Interstitial cystitis (IC) is a type of painful bladder disorder that results in part from ulcerations in the bladder lining and from muscle spasm in the bladder and surrounding area. Although there is no cure for IC as of March 2010, ongoing research had led to numerous new treatments to control IC symptoms. Botox, otherwise known as botulinum toxin and derived from a clostridium bacteria, is an FDA-approved, injected drug that paralyzes muscle. Botox is being studied as a treatment to prevent bladder pain associated with IC.
BOTOX MECHANISM
Botox is a muscle paralyzer and causes muscle relaxation because it prevents chemical activity at nerve-muscle connections in the body. Although pain from IC is possibly caused by acidic foods and irritants in the urine, the symptoms of muscle pain, frequency and urgency are also related to overactive muscle spasms of the bladder. Dr. R. Pinto, et al., reported in European Urology in March 2010 that forced paralysis of the lower bladder wall, the trigone, in particular, with Botox provides direct and lasting improvement of up to nine months in muscle-related symptoms
INJECTION SCHEDULE
In ongoing 2010 studies, 100 units of Botox were injected in different amounts throughout the bladder. In the European Urology study, for example, 10 injections of 10 units each in 1 ml of liquid were injected at a single visit. An ongoing study by the University of Washington is instead providing injections of 25 units to four different parts of the bladder at a single visit. More research is needed to identify the best dose and schedule for injected Botox.
INJECTION LOCATIONS
Use of Botox is still so new in patients with IC that the most appropriate injection location has not been determined. Although the study by Dr. Pinto focused directly on the bottom of the bladder, other research is focusing on areas of the bladder that are specific to individuals. Patients with IC often determine the bladder lining sites of greatest pain during a bladder exam, and Botox might be most useful at these locations. Conversely, treatment directly to the trigone, or bladder bottom, has been proven to improve frequency, urgency and pain.
Read more: http://www.livestrong.com/article/102947-botox-treatments-interstitial-cystitis/#ixzz2hdbxA5PU
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